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Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Adolescent affective symptoms and mortality.

Gemma Archer1, Diana Kuh1, Matthew Hotopf2

  • 1Medical Research Council Unit for Lifelong Health and Ageing,University College London,UK.

The British Journal of Psychiatry : the Journal of Mental Science
|May 29, 2018
PubMed
Summary

Severe adolescent affective problems, like anxiety and depression, are linked to a higher risk of premature death. This association persists even after accounting for other factors, highlighting the need for early mental health support.

Keywords:
Mortalityadolescentaffective disorderscohort studiesdepression

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Area of Science:

  • Epidemiology
  • Developmental Psychology
  • Public Health

Background:

  • Limited understanding of the link between adolescent mental health and long-term mortality.
  • Adolescent affective problems, including anxiety and depression, may impact later life health outcomes.

Purpose of the Study:

  • To investigate the association between adolescent affective symptoms and premature mortality.
  • To determine if this relationship is independent of other developmental factors.

Main Methods:

  • Utilized data from a long-term British birth cohort study (n=3884).
  • Assessed adolescent affective symptoms (mild, moderate, severe) at ages 13 and 15.
  • Tracked mortality up to age 68, adjusting for confounders like social class and cognition.

Main Results:

  • A significant association was found between severe adolescent affective symptoms and increased mortality (HR 1.61).
  • This association remained significant after adjusting for potential confounders.
  • Moderate symptoms showed no significant link to mortality.

Conclusions:

  • Severe adolescent affective symptoms predict a higher risk of premature mortality over 53 years.
  • Early mental health interventions are crucial for long-term well-being.
  • Findings emphasize the lasting impact of adolescent mental health on adult mortality.