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Related Concept Videos

Determining the Plane of Cell Division02:13

Determining the Plane of Cell Division

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Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
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In animal cells, the cleavage furrow forms along the plane of cell division...
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Molecular Factors Affecting Cell Division01:27

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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
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Long Division of Polynomials01:26

Long Division of Polynomials

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Polynomial division is an essential algebraic process to simplify expressions and solve equations. Just as numerical division separates a number into quotient and remainder, polynomial long division partitions a polynomial into simpler components; in this context, the dividend is the polynomial being divided, the divisor is the expression dividing it, and the result is expressed in terms of a quotient and a remainder.The division begins by arranging the dividend and divisor in standard...
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Cranial Part of Parasympathetic Division01:18

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The cranial part of the parasympathetic division plays a crucial role in regulating the visceral functions of the head and specific structures in the neck, thoracic, and abdominopelvic cavities. Preganglionic fibers of the parasympathetic division exit the brain through cranial nerves III (oculomotor), VII (facial), IX (glossopharyngeal), and X (vagus), delivering parasympathetic output to the respective visceral structures.
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Functional Divisions of the Nervous System01:23

Functional Divisions of the Nervous System

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The nervous system, responsible for sensing, integrating, and responding to various stimuli, is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The PNS has two functional divisions: the sensory or afferent division and the motor or efferent division.
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Sympathetic Division of the ANS01:19

Sympathetic Division of the ANS

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The sympathetic division of the autonomic nervous system (ANS) plays a crucial role in preparing the body for stress, physical activity, and increased energy demands. This division activates the "fight-or-flight" response, enabling individuals to respond effectively to challenging situations.
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Related Experiment Video

Updated: Feb 10, 2026

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo
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Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

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Employing the one-cell C. elegans embryo to study cell division processes.

Neil Hattersley1, Pablo Lara-Gonzalez1, Dhanya Cheerambathur1

  • 1Ludwig Institute for Cancer Research, La Jolla, CA, United States; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA, United States.

Methods in Cell Biology
|May 29, 2018
PubMed
Summary

The Caenorhabditis elegans embryo enables precise cell division studies. Researchers developed methods for RNA interference-resistant transgenes and quantitative imaging to analyze chromosome segregation and cytokinesis.

Keywords:
C. elegansCell divisionCentrosomeCytokinesisKinetochoreMeiosisMitosis

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • The one-cell Caenorhabditis elegans embryo is a powerful model for cell division research.
  • Conserved genes and pathways in C. elegans are relevant to other organisms.
  • Precise genetic manipulation is crucial for mechanistic analysis.

Purpose of the Study:

  • To detail methods for generating RNA interference-resistant transgenes in C. elegans.
  • To describe techniques for engineering gene variants and in situ tagging.
  • To outline quantitative imaging assays for cell division analysis.

Main Methods:

  • Generating targeted single-copy RNA interference-resistant transgene insertions.
  • Engineering gene variants at endogenous loci and via transgene insertions.
  • In situ tagging of genes with fluorophores or purification tags.
  • Developing quantitative imaging assays for meiotic and mitotic events.

Main Results:

  • Established robust methods for creating RNA interference-resistant transgenes.
  • Enabled precise perturbation of essential genes and quantitative phenotyping.
  • Facilitated detailed analysis of chromosome segregation, centrosome function, and cytokinesis.

Conclusions:

  • The described techniques enhance the utility of C. elegans for cell division research.
  • These methods allow for quantitative, mechanistic dissection of fundamental biological processes.
  • Findings in C. elegans provide broad relevance to understanding cell division across species.