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Rapid Deletion Production in Fungi via Agrobacterium Mediated Transformation of OSCAR Deletion Constructs
Published on: June 12, 2017
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Long-Distance Relationships: Suppression of Repeat-Mediated Deletions
Maria E Morales1, Tiffany Kaul1, Prescott Deininger1
1Tulane Cancer Center, Tulane University, New Orleans, LA 70122, USA.
Trends in Genetics : TIG
|May 29, 2018
Abstract:
The high proportion of repetitive DNA sequences in the human genome provides tremendous opportunities for DNA rearrangements between non-allelic repetitive elements. The genome must use multiple competing and collaborating repair mechanisms to minimize these types of DNA rearrangements, some of which fail in cancer cells where DNA repair pathways are suppressed.
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