Related Experiment Video

Updated: Feb 10, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.7K

Contribution of routine cardiac biological markers to the etiological workup of ischemic stroke

C Tomich1, J S Liegey1, S Sagnier2

  • 1University of Bordeaux, Bordeaux, France; Bordeaux University Hospital, Stroke Unit, Bordeaux, France.

The American Journal of Emergency Medicine
|May 29, 2018
PubMed

Insights

High B-type natriuretic peptide (BNP) levels measured early after stroke predict cardiac causes. This biomarker can help identify patients needing further cardiac evaluation, improving cardio-embolic stroke detection.

Area of Science:

  • Neurology
  • Cardiology
  • Biomarkers

Background:

  • Atrial fibrillation detection post-stroke is crucial but long-term monitoring is often limited.
  • Identifying cardio-embolic stroke mechanisms aids in targeted treatment and prevention.

Purpose of the Study:

  • To evaluate the utility of routine biological markers (troponin, D-dimers, BNP) in identifying cardio-embolic stroke risk.
  • To assess if these markers measured during the acute phase can predict stroke mechanism.

Main Methods:

  • Troponin, D-dimers, and BNP levels were measured in 634 ischemic stroke patients within 48 hours of admission.
  • Stroke mechanisms were classified at 3-month follow-up using the ASCOD classification.
  • Logistic regression analyzed associations between clinical, radiological, and biological markers and stroke mechanism.

Main Results:

  • A cardiac mechanism was identified in 25.1% of patients.
  • Multivariate analysis linked initial stroke severity, heart failure history, ECG abnormalities, and high BNP levels to cardiac stroke mechanisms.
  • High BNP (OR 4.34) was a significant independent predictor of cardiac stroke.

Conclusions:

  • Early measurement of B-type natriuretic peptide (BNP) is an independent predictor of cardiac stroke mechanisms.
  • BNP measurement can optimize the selection of patients for further cardiologic investigations, including long-term ECG monitoring.
  • BNP should be incorporated into the standard stroke admission work-up.
Abstract

More Related Videos

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

1.6K
Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke09:00

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Published on: February 10, 2023

1.7K

Related Concept Videos

Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
3.5K
Cardiac Output and Stroke Volume01:11

Cardiac Output and Stroke Volume

Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac...
4.9K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
570
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
612
Binet's Contribution to Measures of Intelligence01:23

Binet's Contribution to Measures of Intelligence

Alfred Binet, along with his student Théophile Simon, was tasked by the French Ministry of Education in 1904 to create a method for identifying students who struggled to learn through conventional classroom instruction. This initiative aimed to address overcrowding by placing such students in specialized schools. Binet and Simon developed an intelligence test comprising 30 tasks, ranging from simple commands, like touching one's nose or ear, to more complex tasks, such as drawing...
1.8K
Wechsler's Contribution to Measures of Intelligence01:23

Wechsler's Contribution to Measures of Intelligence

David Wechsler, a psychologist who worked with World War I veterans, developed a significant IQ test in 1939 called the Wechsler-Bellevue Intelligence Scale. This test was innovative because it combined several subtests that measured both verbal and nonverbal skills, reflecting Wechsler's belief that intelligence is a global capacity involving purposeful action, rational thinking, and effective interaction with the environment. This test later evolved into the Wechsler Adult Intelligence...
2.1K