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Updated: Feb 10, 2026
12:18
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
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Persistent methicillin-resistant Staphylococcus aureus bacteremia owing to placental abscess
Naomi Maeda1, Hideharu Hagiya1, Tsuyoshi Takiuchi2
1Division of Infection Control and Prevention, Osaka University Hospital, Japan.
Summary
Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia in a pregnant woman was linked to a placental abscess. This rare case highlights the importance of considering placental infection as a source of persistent MRSA bacteremia.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Pathology
Background:
- Staphylococcus aureus is an emerging pathogen in human gestational membranes, potentially causing chorioamnionitis.
- Methicillin-resistant S. aureus (MRSA) infections in pregnancy require careful management due to limited treatment options.
Observation:
- A 29-year-old pregnant woman with acute promyelocytic leukemia developed persistent MRSA bacteremia despite multiple antimicrobial therapies.
- The patient experienced 12 episodes of MRSA bacteremia over six weeks, with the source initially unknown.
Findings:
- Pathologic examination of the placenta revealed an abscess, confirming MRSA-associated chorioamnionitis.
- Molecular analysis identified a single MRSA strain (SCCmec Type IVa) responsible for the persistent infection.
Implications:
- Persistent MRSA bacteremia in pregnant women may originate from placental abscesses.
- This case underscores the need for heightened awareness and diagnostic consideration of placental infections in cases of refractory bacteremia during pregnancy.
Keywords:
ChorioamnionitisFebrile neutropeniaLeukemiaMethicillin-resistant Staphylococcus aureusPersistent bacteremiaStaphylococcus aureus bacteremiaMore Related Videos
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