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The spectrum of multiple sclerosis lesions using a multiple spin echo pulse sequence and a high field strength
V B Graves1, P A Turski, C M Strother
1Department of Radiology, University of Wisconsin, Madison 53792.
Acta Radiologica. Supplementum
|January 1, 1986
Summary
Multiple spin echo MRI effectively detects multiple sclerosis (MS) lesions in 94% of patients. This sensitive imaging method aids in diagnosing MS by identifying characteristic lesions throughout the brain and brainstem.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Accurate detection of MS lesions is crucial for diagnosis and management.
- Magnetic Resonance (MR) imaging is a key tool in MS diagnostics.
Purpose of the Study:
- To evaluate the sensitivity of multiple spin echo MR sequences in detecting lesions consistent with multiple sclerosis.
- To correlate MR-detected lesions with known pathological data in MS patients.
Main Methods:
- Seventy-one patients with clinical findings suggestive of MS underwent MR imaging.
- A 1.5 tesla MR instrument was used with multiple spin echo sequences (TR = 2,000 ms, TE = 30, 60, 90, 120 ms).
Main Results:
- Multiple spin echo imaging identified MS-consistent lesions in 67 out of 71 patients (94%).
- Detected lesions correlated with pathological data, except in the cortex, optic nerve, and chiasm.
- Lesions were predominantly multiple in the cerebral hemispheres, corpus callosum, and cerebellum, and singular in the brain stem and optic tracts.
- Most lesions were located within the white matter tracts of the cerebral hemispheres and brain stem.
Conclusions:
- Multiple spin echo MR sequences demonstrate high sensitivity for detecting lesions in patients with multiple sclerosis.
- This technique aids in characterizing lesion distribution and aids in the diagnosis of MS.