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Regional cerebral blood flow changes in aging.

K Iwata1, H Harano

  • 1Department of Neurologic Surgery, Aichi Medical University, Japan.

Acta Radiologica. Supplementum
|January 1, 1986
PubMed
Summary

Cerebral blood flow shows minimal age-related decline, but cerebrovascular resistance increases after age forty, linked to rising blood pressure in healthy adults.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Cardiovascular Science

Background:

  • Aging impacts physiological functions, including cerebral blood flow and cerebrovascular resistance.
  • Understanding age-related changes in brain circulation is crucial for maintaining cognitive health.

Purpose of the Study:

  • To investigate regional cerebral blood flow (rCBF) and cerebrovascular resistance (CVR) changes in healthy aging adults.
  • To determine the correlation between aging, blood pressure, and cerebral hemodynamics.

Main Methods:

  • Utilized 131Xe inhalation and emission computed tomography for rCBF measurement.
  • Studied 38 healthy volunteers aged 23-65 years, excluding hypertensive individuals.

Main Results:

  • A slight, non-significant negative correlation was observed between rCBF and age.
  • Cerebrovascular resistance (CVR) showed a significant positive correlation with aging.
  • CVR increased notably after age forty compared to younger age groups, associated with elevated blood pressure.

Conclusions:

  • While regional cerebral blood flow remains relatively stable in healthy aging, cerebrovascular resistance significantly increases.
  • Elevated blood pressure appears to be a key factor driving increased cerebrovascular resistance with age.

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