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Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future

Fengna Chu1, Mingchao Shi1, Yue Lang1

  • 1Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, Jilin Province, China.

Mediators of Inflammation
|May 29, 2018
PubMed

Insights

Gut microbiome dysbiosis is linked to multiple sclerosis (MS). Research suggests that modulating the gut microbiota could be a potential future treatment strategy for MS patients.

Area of Science:

  • Neuroimmunology
  • Gastroenterology
  • Microbiome Research

Background:

  • Gut microbiome dysbiosis is implicated in various human disorders, including autoimmune diseases like multiple sclerosis (MS).
  • The exact causes of MS are unknown, but likely involve genetic and environmental factors.
  • Emerging evidence highlights the role of gastrointestinal microbiota in the pathogenesis of MS and its animal model, EAE.

Purpose of the Study:

  • To review the characteristics of gut microbiota.
  • To explore the gut-brain axis connection.
  • To discuss alterations in gut microbiota composition in MS/EAE and potential therapeutic applications.

Main Methods:

  • Literature review of studies on gut microbiota and MS/EAE.
  • Analysis of the gut-brain axis.
  • Exploration of microbiota-based therapeutic strategies.

Main Results:

  • Gut microbiota plays a significant role in the pathogenesis of MS/EAE.
  • Dysbiosis of the gut microbiome is observed in MS.
  • The gut-brain axis is a critical pathway influencing MS.

Conclusions:

  • Gut microbiome alterations are associated with MS.
  • Modulating the gut microbiota presents a promising avenue for MS treatment.
  • Further research into microbiota therapies for MS is warranted.

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