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Short-distance transport refers to transport that occurs over a distance of just 2-3 cells, crossing the plasma membrane in the process. Small uncharged molecules, such as oxygen, carbon dioxide, and water, can diffuse across the plasma membrane on their own. In contrast, ions and larger molecules require the assistance of transport proteins due to their charge or size. Transport across membranes also occurs within individual cells, playing a variety of essential roles for the plant as a whole.
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The Cellosaurus, a Cell-Line Knowledge Resource.

Amos Bairoch1

  • 1Computer and Laboratory Investigation of Proteins of Human Origin Group, Faculty of Medicine, Swiss Institute of Bioinformatics, University of Geneva, Geneva 4, Switzerland.

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|May 29, 2018
PubMed
Summary
This summary is machine-generated.

The Cellosaurus is a comprehensive database detailing over 100,000 cell lines for biomedical research. This resource aids scientists in identifying misidentified cell lines, enhancing life science research quality.

Keywords:
bioinformaticscomputational biologydatabase

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Area of Science:

  • Biomedical Research
  • Cell Line Characterization
  • Life Sciences

Background:

  • Cell lines are fundamental tools in biomedical research.
  • Accurate cell line identification is crucial for reproducible scientific outcomes.
  • Existing resources may lack comprehensive coverage or detailed annotations.

Purpose of the Study:

  • To establish and maintain a comprehensive knowledge resource for all cell lines used in biomedical research.
  • To provide detailed information, cross-references, and literature citations for each cell line.
  • To facilitate the identification of misidentified or contaminated cell lines.

Main Methods:

  • Aggregating data from diverse sources to describe cell lines.
  • Providing detailed annotations including origin, species, and genetic information.
  • Maintaining an accessible online platform with downloadable data.

Main Results:

  • The Cellosaurus currently describes over 100,000 cell lines.
  • Information includes extensive details, cross-references, and literature citations.
  • The resource is accessible online and available for download.

Conclusions:

  • The Cellosaurus is an invaluable resource for the life sciences community.
  • It significantly contributes to improving research quality by enabling accurate cell line identification.
  • The database supports reproducibility and reliability in biomedical research.