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Chronological Echocardiographic Changes in Healthy Term Neonates within Postnatal 72 Hours Using Doppler Studies

Kee Soo Ha1, Byung Min Choi2, Eun Hee Lee3

  • 1Department of Pediatrics, Korea University Guro Hospital, Seoul, Korea.

Journal of Korean Medical Science
|May 29, 2018
PubMed

Insights

Postnatal 24 hours is critical for hemodynamic changes in neonates, with significant shifts in echocardiographic parameters indicating patent ductus arteriosus (PDA) closure. These findings help establish normal neonatal cardiovascular baselines.

Area of Science:

  • Neonatal cardiology
  • Pediatric echocardiography
  • Cardiovascular physiology

Background:

  • Echocardiographic changes in healthy neonates during the early transitional period (0-72 hours postnatal) are not fully characterized.
  • Understanding these changes is crucial for assessing neonatal cardiovascular adaptation.

Purpose of the Study:

  • To evaluate echocardiographic parameters in full-term healthy neonates at 12-hour intervals from 0 to 72 hours postnatal.
  • To identify critical time points for hemodynamic changes and patent ductus arteriosus (PDA) closure.

Main Methods:

  • Prospective, observational, longitudinal cohort study of 56 healthy, full-term neonates.
  • Echocardiography assessed morphometric, functional, systolic, diastolic, and tissue Doppler imaging (TDI) parameters of the left ventricle (LV) and right ventricle (RV).
  • Evaluated parameters included PDA, aorta, SVC, SV, CO, CI, E, A, E', S', A', and MPI.

Main Results:

  • Significant changes in PDA size and velocity, aortic VTI, BP, LV SV/kg, LV CO/kg, LV CI, and SVC flow/LV CO were observed before and after 24 hours postnatal.
  • LV and RV MPI were significantly higher before 24 hours compared to after.
  • LV E/E' was significantly higher than RV E/E'.

Conclusions:

  • Postnatal 24 hours represents a critical period for the hemodynamic closure of PDA.
  • Simultaneous significant changes in aortic VTI, BP, LV SV, LV CO, LV CI, and SVC flow/LV CO occur around 24 hours.
  • These chronological changes in systolic, diastolic, and TDI parameters can establish normal baseline data for healthy neonates.
Abstract

Keywords:
DopplerEchocardiographyNeonateTerm Birth

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