Related Experiment Video

Updated: Feb 10, 2026

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
07:57

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

Published on: June 24, 2025

1.2K

Use of a chlorhexidine-impregnated dressing reduced catheter-related bloodstream infections caused by Gram-positive

Ayse Betul Ergul1, Ikbal Gokcek2, Alper Ozcan3

  • 1Ayse Betul Ergul, M.D. Department of Pediatric Intensive Care Unit, University of Health Sciences, Kayseri Training and Research Hospital, Kayseri, Turkey.

Pakistan Journal of Medical Sciences
|May 29, 2018
PubMed

Insights

Chlorhexidine Gluconate (CHG) dressings showed a significant reduction in Gram-positive Catheter-Related Bloodstream Infections (CRBSIs). While overall CRBSI rates were similar, CHG dressings proved effective against specific bacterial types.

Area of Science:

  • Infection Control
  • Medical Device Associated Infections
  • Antimicrobial Stewardship

Background:

  • Catheter-Related Bloodstream Infections (CRBSIs) are a significant concern in intensive care settings.
  • Transparent dressings are commonly used for vascular access sites, but their antimicrobial properties vary.
  • Chlorhexidine Gluconate (CHG) is a broad-spectrum antiseptic with proven efficacy against various microorganisms.

Purpose of the Study:

  • To compare the effectiveness of Chlorhexidine Gluconate (CHG)-impregnated dressings versus standard non-antimicrobial transparent dressings in preventing CRBSIs.
  • To evaluate the impact of CHG dressings on the incidence of CRBSIs, specifically focusing on causative microorganisms.

Main Methods:

  • A prospective, comparative, single-center clinical study was conducted in a pediatric intensive care unit.
  • Patients with jugular vein catheterization for ≥48 hours were included.
  • The study utilized a crossover design with alternating phases of standard non-antimicrobial dressings and CHG-impregnated dressings to mitigate temporal biases.

Main Results:

  • The study included 68 patients in the standard-dressing group and 63 in the CHG-dressing group, with similar catheterization durations.
  • The overall CRBSI rate was slightly lower in the CHG group (20.6%) compared to the standard group (26.5%), but this difference was not statistically significant.
  • A statistically significant reduction in CRBSIs caused by Gram-positive microorganisms was observed in the CHG-dressing group (0%) compared to the control group (8.8%; p=0.028).

Conclusions:

  • Chlorhexidine Gluconate (CHG) dressings significantly reduce CRBSIs caused by Gram-positive microorganisms.
  • While overall CRBSI rates did not differ significantly, CHG dressings offer targeted protection against specific pathogens, contributing to infection control strategies.
Abstract

Keywords:
Catheter securementCatheter-related bloodstream infectionChlorhexidine dressingIntensive care

More Related Videos

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging03:24

Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging

Published on: March 22, 2024

2.1K
A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

13.8K

Related Concept Videos

Types of Microorganisms01:29

Types of Microorganisms

Microorganisms are a diverse group of microscopic entities broadly categorized into cellular and acellular types based on their structural organization. Cellular microorganisms include bacteria, archaea, fungi, protozoa, and algae, while acellular microorganisms are represented by viruses.Cellular MicroorganismsBacteriaBacteria, tiny prokaryotic organisms, exhibit fascinating shapes such as rods, spheres, and spirals. They adapt to diverse habitats, including soil, water, and human-associated...
2.5K
Mutations in Microorganisms01:18

Mutations in Microorganisms

Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
751
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
7.1K
Environmental Applications of Microorganisms01:30

Environmental Applications of Microorganisms

Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
1.2K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.1K
Microorganisms in Agriculture and Food industry01:27

Microorganisms in Agriculture and Food industry

Microorganisms play a crucial role in agriculture and the food industry, contributing to soil fertility, crop protection, and food production. Their functions range from nitrogen fixation and biopesticide production to fermentation and food preservation, making them indispensable to sustainable farming and food safety.Role in AgricultureNitrogen-fixing bacteria, such as Rhizobium (symbiotic) and Azotobacter (free-living), convert atmospheric nitrogen into ammonia through biological nitrogen...
1.6K