Related Experiment Video

Updated: Feb 10, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Intraventricular Dyssynchrony among patients with left bundle branch block

Abdul Sami1, Malik Faisal Iftekhar2, Imran Khan3

  • 1Dr. Abdul Sami, FCPS. Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan.

Pakistan Journal of Medical Sciences
|May 29, 2018
PubMed

Insights

Intraventricular dyssynchrony is common in patients with left bundle branch block (LBBB), particularly those with heart failure. This condition affects a significant majority of LBBB patients, highlighting its clinical importance.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Electrophysiology

Background:

  • Left bundle branch block (LBBB) can lead to cardiac dyssynchrony.
  • Intraventricular dyssynchrony may impact heart failure outcomes.
  • Understanding the prevalence of dyssynchrony in LBBB is crucial for patient management.

Purpose of the Study:

  • To determine the frequency of intraventricular dyssynchrony in patients diagnosed with left bundle branch block.
  • To assess the association between intraventricular dyssynchrony and heart failure in LBBB patients.

Main Methods:

  • The study included 159 adult patients with LBBB on ECG.
  • Exclusion criteria included valvular heart disease, recent coronary events, and atrial fibrillation.
  • Tissue Doppler Imaging (TDI) was used to measure dyssynchrony parameters.

Main Results:

  • A high prevalence of intraventricular dyssynchrony was observed in 78% of LBBB patients.
  • 65% of the study population had co-existing heart failure.
  • Dyssynchrony was more prevalent in patients with heart failure.

Conclusions:

  • The incidence of intraventricular dyssynchrony is notably high in patients with left bundle branch block and heart failure.
  • These findings underscore the importance of evaluating for dyssynchrony in this patient group.
Abstract

Keywords:
Intraventricular dyssynchronyLeft bundle branch block

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