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Colonic Abnormalities in Manitoban Children with Helicobacter pylori Gastritis
Upama Banik1, Camelia Stefanovici1, Jennifer Griffin1
1Section of Pediatric Gastroenterology, Departments of Pediatrics and Pathology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Insights
Helicobacter pylori (H. pylori) gastritis in children may be linked to colonic changes. A study found that 59% of children with H. pylori gastritis who underwent colonoscopy showed significant findings, suggesting a potential association.
Area of Science:
- Pediatric Gastroenterology
- Microbiology
- Colorectal Pathology
Background:
- The association between Helicobacter pylori (H. pylori) infection and colonic pathology is not well-established.
- H. pylori gastritis is a common diagnosis in children, but its impact on the colon requires further investigation.
Purpose of the Study:
- To investigate the prevalence and characteristics of colonic changes in pediatric patients diagnosed with H. pylori gastritis.
- To explore potential links between H. pylori infection and colonic abnormalities in children.
Main Methods:
- A retrospective review of medical records for Manitoban children (≤17 years) diagnosed with H. pylori gastritis between January 1996 and May 2015.
- Identification of patients who underwent colonoscopy, with documentation of demographics, indications, endoscopic findings, and histopathological results.
Main Results:
- Out of 231 children with H. pylori gastritis, 37 (16%) underwent colonoscopy.
- Significant endoscopic and histopathological findings, including polyposis and colitis, were observed in 22 (59%) of these children.
- Boys with colonic changes were diagnosed at a younger age (11.5 years) compared to those without (15.0 years).
Conclusions:
- The study suggests a potential association between H. pylori infection and specific colonic changes in the pediatric population.
- Further research is warranted to elucidate the mechanisms underlying this observed association.
Objectives:
Association between Helicobacter pylori (H. pylori) and colonic pathology is underinvestigated. The aim of this work was to examine the prevalence and nature of colonic changes in children diagnosed with H. pylori gastritis.
Methods:
A comprehensive retrospective review of the medical records for all Manitoban children (≤17 years) diagnosed with H. pylori gastritis from January 1996 to May 2015 was conducted. Children with H. pylori gastritis who had colonoscopy were identified. Patients' demographics, indications for colonoscopy, laboratory and endoscopic findings, and colonic histopathological abnormalities were documented.
Results:
A total of 231 children were found to have H. pylori gastritis. The mean age at diagnosis was 12.3 ± 4.1 years; 108 (46.6%) were girls. Of the 231 patients, 37 (16%) patients were found to have colonoscopy performed. Indications for colonoscopy included bleeding per rectum, significant weight loss, and hypoalbuminemia. Twenty-two (59%) of 37 children who had colonoscopy had significant endoscopic and histopathological findings on colonoscopy including polyposis and colitis. Boys with colonic changes were diagnosed at an earlier age compared to those without (11.5 ± 7.0 versus 15.0 ± 2.0, p < 0.049).
Conclusions:
Our study may suggest a possible association between H. pylori and a subset of colonic changes in children.
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