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Relationship between HOX gene and pediatric congenital clubfoot

Yuanhui Wang1

  • 1Department of the Bone and Joint Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Experimental and Therapeutic Medicine
|May 29, 2018
PubMed

Insights

Abnormal expression of the HOX gene is linked to pediatric congenital clubfoot (CCF). This study found HOX gene expression, inflammation, and apoptosis were higher in CCF patients, suggesting HOX

Area of Science:

  • Pediatric Orthopedics
  • Developmental Biology
  • Molecular Genetics

Background:

  • Congenital clubfoot (CCF) is a common pediatric deformity.
  • The genetic and molecular underpinnings of CCF require further elucidation.
  • Transcription factor homeobox (HOX) genes play critical roles in embryonic development.

Purpose of the Study:

  • To investigate the relationship between HOX gene expression and pediatric congenital clubfoot (CCF).
  • To explore the roles of oxidative damage, inflammation, and apoptosis in CCF pathogenesis.
  • To assess the potential of HOX gene expression as a diagnostic marker for CCF.

Main Methods:

  • Serum levels of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) were measured.
  • Inflammatory markers (IL-1β, IL-6, TNF-α) and apoptosis-related factors (Fas, FasL, Bax) were detected using RT-PCR.
  • HOX gene mRNA and protein expression levels were analyzed via RT-PCR and Western blot.

Main Results:

  • CCF patients exhibited significantly higher levels of iNOS, NO, inflammatory markers, and apoptosis-related factors compared to controls.
  • HOX gene expression (mRNA and protein) was significantly upregulated in CCF tissues.
  • Statistical analysis confirmed a significant difference in HOX expression between CCF and control groups (P<0.01).

Conclusions:

  • Abnormal HOX gene expression is closely associated with the development of pediatric congenital clubfoot.
  • Oxidative damage, inflammation, and apoptosis are implicated in CCF pathogenesis.
  • HOX gene expression shows potential as a diagnostic and therapeutic indicator for CCF.

Keywords:
congenital clubfoothomeobox genepediatric

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