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Prognostic and therapeutic value of CD103+ cells in renal cell carcinoma

Jin Zhou1, Lipeng Liu1, Tuo Yang1

  • 1Department of Urology, Tianjin Nankai Hospital, Tianjin 300100, P.R. China.

Experimental and Therapeutic Medicine
|May 29, 2018
PubMed

Insights

High CD103+ cell counts are a favorable prognostic indicator in renal cell carcinoma (RCC) patients. Expanding these cells may improve the effectiveness of immune checkpoint blockade therapy (ICBT) in treating RCC.

Area of Science:

  • Immunology
  • Oncology
  • Cancer Research

Background:

  • Immune checkpoint blockade therapy (ICBT) shows promise but lacks efficacy in many cancer patients.
  • Renal cell carcinoma (RCC) remains a significant cause of cancer mortality with limited treatment options for advanced stages.

Purpose of the Study:

  • To investigate the prognostic value of CD103+ cells in RCC.
  • To determine if CD103+ cells can enhance the efficacy of ICBT in RCC.

Main Methods:

  • Analysis of CD103+ cell counts and survival in 200 RCC patient tumor samples.
  • Evaluation of CD103+ cell function in combination with ICBT using an RCC mouse model.

Main Results:

  • A high CD103+ cell count was identified as an independent favorable prognostic factor in RCC.
  • Expansion of CD103+ cells enhanced ICBT effects in an RCC mouse model, while depletion reduced efficacy.
  • CD103+ cell expansion increased the number and activation of tumor-infiltrating CD8+ T cells in RCC.

Conclusions:

  • Elevated CD103+ cell counts signify a positive prognosis for RCC patients.
  • Strategies to expand CD103+ cells could potentially improve ICBT response rates in RCC treatment.
Keywords:
CD103+ cellsimmune checkpoint blockade therapyprognosisrenal cell carcinomasurvival

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