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Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
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Expression of tumor suppressor programmed cell death 4 in endometrioid endometrial carcinomas and clinicopathological

Yanping Liu1, Han Sun2,3, Hongju Mao4

  • 1Department of Gynecology and Obstetrics, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China.

Oncology Letters
|May 29, 2018
PubMed

Insights

Programmed cell death 4 (PDCD4) expression is reduced in endometrioid endometrial carcinoma (EEC), particularly in higher-grade tumors. Lower PDCD4 levels correlate with increased tumor malignancy, suggesting its potential as a prognostic marker.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Programmed cell death 4 (PDCD4) is a tumor suppressor implicated in various cancers.
  • PDCD4 expression and its clinical significance in endometrial cancer are not well-established.

Purpose of the Study:

  • To investigate PDCD4 expression in endometrioid endometrial carcinoma (EEC).
  • To analyze the association between PDCD4 expression and clinicopathological parameters in EEC.

Main Methods:

  • Reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
  • Western blotting.
  • Immunohistochemistry and immunocytochemistry.

Main Results:

  • PDCD4 expression was detected in the cytoplasm of endometrial cells and EEC cells.
  • PDCD4 levels were significantly decreased in grade 2/3 EEC compared to normal endometrium.
  • PDCD4 expression was significantly associated with tumor grade, with higher levels in grade 1 EEC.

Conclusions:

  • PDCD4 expression is downregulated in EEC, particularly in higher-grade tumors.
  • PDCD4 is associated with the histological grade of EEC.
  • PDCD4 may serve as a valuable indicator of tumor malignancy in EEC.
Keywords:
endometrial cancerprogrammed cell death 4tumor gradetumor suppressor gene

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