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Oxidative stress in female cancers
Gloria M Calaf1,2, Ulises Urzua3, Lara Termini4
1Instituto de Alta Investigación (IAI), Universidad de Tarapacá, Arica, Chile.
Oncotarget
|May 29, 2018
Summary
Oxidative stress (OS) and reactive oxygen species (ROS) are linked to breast, cervical, and ovarian cancers. Natural antioxidants like curcumin may offer prevention and treatment strategies for these prevalent women's cancers.
Area of Science:
- Oncology
- Biochemistry
- Environmental Health
Background:
- Breast, cervical, and ovarian cancers are significant global health concerns for women.
- Environmental, hormonal, and viral factors are implicated in the etiology of these cancers.
- Oxidative stress (OS), an imbalance in reactive oxygen species (ROS) and detoxification, plays a crucial role in cancer development.
Purpose of the Study:
- To review the role of OS in the initiation, promotion, and progression of breast, cervical, and ovarian cancers.
- To explore the interplay between OS and environmental, host, and viral factors in these cancers.
- To discuss the potential of natural compounds, such as curcumin, in cancer prevention and treatment.
Main Methods:
- Literature review focusing on oxidative stress and gynecological cancers.
- Analysis of the relationship between environmental, hormonal, and viral factors and OS.
- Evaluation of antioxidant compounds for cancer prevention and treatment.
Main Results:
- OS is a key mechanism linking various factors to cancer development.
- Specific environmental, host, and viral factors contribute to OS in breast, cervical, and ovarian cancers.
- Natural antioxidants show promise for therapeutic and preventative applications.
Conclusions:
- Oxidative stress is a critical factor in the pathogenesis of major women's cancers.
- Understanding the interplay of OS with external and internal factors is vital for targeted interventions.
- Antioxidant compounds, particularly curcumin, represent a potential avenue for novel cancer prevention and treatment strategies.
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