Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.6K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.6K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

2.9K
2.9K
Computed Tomography01:10

Computed Tomography

8.8K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
8.8K
Bone Disorders01:29

Bone Disorders

5.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.4K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.3K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.3K
Disorders of Leukocytes01:27

Disorders of Leukocytes

2.0K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

VDR/RXR antagonizes calcineurin-activated NFAT1, an essential regulator of Coronin-1A expression and Mycobacterial persistence.

The Biochemical journal·2026
Same author

Integrating molecular dynamics simulations to enable rational assembly of immune signals for immunotherapy.

Nanoscale horizons·2026
Same author

Biomolecular Condensates Act as Distinct Solvation Environments That Reshape Amino Acid p<i>K</i><sub>a</sub> Values.

Journal of the American Chemical Society·2026
Same author

Learning molecular determinants of selective small-molecule partitioning across biomolecular condensates.

bioRxiv : the preprint server for biology·2026
Same author

Mechanistic Insights into Molecular Modifiers That Promote Urate Crystallization through Solute Assembly Regulation.

JACS Au·2026
Same author

Enhanced Hypoglycemic Activity of Metformin with the Reduction of the Particle Size.

Biotechnology and applied biochemistry·2026
Same journal

From Fundamental Photophysics to Photocatalysis: Energy Gap Law Analysis of Anion Radical Excited States.

ACS central science·2026
Same journal

Mechanical Taming of Hardy-Cope Rearrangements.

ACS central science·2026
Same journal

Validation of <i>De Novo</i> Designs of Solid-Binding Peptides.

ACS central science·2026
Same journal

These Graphene Experts Are Trying to Close the Reproducibility Gap in Two-Dimensional Materials Research.

ACS central science·2026
Same journal

How to Make a Creamy, Tasty Vegan Camembert.

ACS central science·2026
Same journal

Versatile Pyridinium Trifluoroborate Platform for Facile Preparation of <sup>18</sup>F‑Labeled PET Tracers in Water.

ACS central science·2026
See all related articles

Related Experiment Video

Updated: Feb 10, 2026

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
07:24

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

Published on: September 23, 2021

2.3K

Looking at the Disordered Proteins through the Computational Microscope.

Payel Das1, Silvina Matysiak2, Jeetain Mittal3

  • 1IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598, United States.

ACS Central Science
|May 29, 2018
PubMed
Summary
This summary is machine-generated.

Intrinsically disordered proteins (IDPs) are crucial in cell functions and disease. Molecular simulations offer a powerful way to understand IDP structure-function relationships, aiding drug discovery efforts.

More Related Videos

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

2.6K
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

3.2K

Related Experiment Videos

Last Updated: Feb 10, 2026

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
07:24

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins

Published on: September 23, 2021

2.3K
Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

2.6K
Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

3.2K

Area of Science:

  • Biochemistry
  • Computational Biology
  • Structural Biology

Background:

  • Intrinsically disordered proteins (IDPs) are prevalent in proteomes and play vital roles in cellular processes and diseases.
  • Many IDPs are targets for therapeutic interventions, but their flexible nature complicates structure-function analysis.
  • Understanding the dynamic structures of IDPs is essential for deciphering their biological functions.

Purpose of the Study:

  • To review molecular simulation methods for studying intrinsically disordered proteins.
  • To highlight example applications of simulations in IDP research.
  • To provide an outlook on improving simulation techniques for IDPs.

Main Methods:

  • Utilizing various molecular simulation techniques across different length and time scales.
  • Complementing experimental approaches with atomic-level characterizations via simulations.
  • Applying multi-resolution simulation strategies to capture IDP dynamics.

Main Results:

  • Molecular simulations are indispensable tools for investigating IDP structure and function.
  • Simulations provide mechanistic insights into the roles of IDPs in physiology and pathology.
  • Current simulation methods offer valuable, though improvable, descriptions of IDP behavior.

Conclusions:

  • Molecular simulations are key to understanding the structure-function paradigm of intrinsically disordered proteins.
  • Advancements in simulation methodologies will enhance the accuracy of IDP studies.
  • Improved simulations will facilitate the development of IDP-targeted therapeutics.