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Related Experiment Video

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In Vivo Modeling of the Morbid Human Genome using Danio rerio
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A blueprint for human whole-cell modeling.

Balázs Szigeti1,2, Yosef D Roth1,2, John A P Sekar1,2

  • 1Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.

Current Opinion in Systems Biology
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Summary
This summary is machine-generated.

Creating whole-cell dynamical models of human cells is a key systems biology goal. A proposed project outlines a plan for developing these complex models, advancing cell biology and disease treatment.

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Area of Science:

  • Systems biology
  • Computational biology
  • Human cell biology

Background:

  • Whole-cell dynamical models are crucial for understanding human cell biology and disease.
  • Significant challenges exist in developing these comprehensive models.
  • Existing models of individual cellular pathways provide a foundation.

Purpose of the Study:

  • To propose a strategic plan for the development of human whole-cell models.
  • To outline a project, the Human Whole-Cell Modeling Project, to achieve this goal.
  • To identify key areas for technological and collaborative advancement.

Main Methods:

  • Analysis of existing individual cellular pathway models.
  • Survey of the biomodeling community's expertise and needs.
  • Leveraging experience from developing whole-cell models of bacteria.

Main Results:

  • A comprehensive plan for the Human Whole-Cell Modeling Project has been formulated.
  • Key foundational elements include technology development, standards development, and interdisciplinary collaboration.
  • The feasibility of human whole-cell models is considered rapidly advancing.

Conclusions:

  • Human whole-cell models are becoming increasingly achievable.
  • A structured, collaborative project is essential for success.
  • Advancements in this area promise significant impacts on biological research and medical treatment.