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Solvents01:12

Solvents

71.3K
A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
71.3K
Titration in Nonaqueous Solvents01:16

Titration in Nonaqueous Solvents

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Most acid-base titrations are performed in an aqueous medium. In aqueous titrations, water competes with weaker acids or bases for proton donation or acceptance, leading to ambiguous endpoints in the titration curve. Water also affects the partial ionization of weak acids or bases. For example, water accepts a proton from acetic acid to form hydronium and acetate ions. The hydronium ion formed is a stronger acid than acetic acid, and the acetate ion is a stronger base than water. As a result,...
1.4K
Dry Friction01:30

Dry Friction

996
Dry friction occurs between two solid surfaces in contact as they attempt to move relative to one another. In daily life, dry friction is encountered in various forms, such as when walking on the ground, sliding an object across a table, or rubbing hands together. Despite its ubiquity, the underlying mechanisms behind dry friction are not readily visible.
To illustrate this concept, imagine a wooden crate resting on a rough, non-uniform horizontal surface. When an external force is applied to...
996
Drying Shrinkage01:21

Drying Shrinkage

385
When hardened concrete is exposed to air with a relative humidity of less than 100 percent, it begins to lose the free water within its capillaries. As this water evaporates, the water initially adsorbed onto the calcium silicate hydrates migrates towards these now empty spaces and eventually evaporates as well. Over time, as more water leaves, the volume of the concrete decreases, a phenomenon known as drying shrinkage.
A portion of this drying shrinkage can be reversed; if the concrete is...
385
Autophagic Cell Death01:18

Autophagic Cell Death

4.6K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.6K
Overview of Cell Death01:30

Overview of Cell Death

10.2K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
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Updated: Feb 10, 2026

Preparation of Biopolymer Aerogels Using Green Solvents
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Preparation of Biopolymer Aerogels Using Green Solvents

Published on: July 4, 2016

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Two Laboratory Deaths, and Keeping Organic Solvents Dry.

Pierre Laszlo1,2,3

  • 1Ecole polytechnique, Palaiseau, France.

Angewandte Chemie (International Ed. in English)
|May 29, 2018
PubMed
Summary

Molecular sieves, pioneered by Saul Winstein, have evolved for drying organic solvents, enhancing laboratory safety and advancing physical organic chemistry research.

Keywords:
Stork, GilbertWinstein, Saulhumidityphysical organic chemistryzeolites

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Area of Science:

  • Chemistry
  • Physical Organic Chemistry

Background:

  • The use of molecular sieves for drying organic solvents has a significant history.
  • Saul Winstein is credited with pioneering this technique.

Purpose of the Study:

  • To discuss the historical evolution of molecular sieve usage in drying organic solvents.
  • To relate this evolution to laboratory safety improvements.
  • To connect this development to the rise of physical organic chemistry.

Main Methods:

  • Historical review of scientific literature.
  • Analysis of laboratory safety protocols.
  • Examination of the development of physical organic chemistry.

Main Results:

  • Molecular sieves have become a standard and safe method for drying organic solvents.
  • Their adoption improved the reliability of experiments in physical organic chemistry.

Conclusions:

  • The historical use of molecular sieves for solvent drying has significantly impacted laboratory safety and the development of physical organic chemistry.