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Outcome and prognostic factors in medically treated canine prostatic carcinomas: A multi-institutional study
S Ravicini1, S J Baines1, A Taylor2
1Willows Veterinary Centre and Referral Service, Solihull, West Midlands, UK.
Veterinary and Comparative Oncology
|May 29, 2018
Summary
Treating canine prostatic carcinoma (PC) with non-steroidal anti-inflammatory drugs (NSAIDs) and chemotherapy offers improved outcomes. Combination therapy significantly increased median survival time (MST) and time to progression (TTP) compared to NSAIDs alone. Metastatic disease and intact status negatively impacted prognosis.
Area of Science:
- Veterinary Oncology
- Canine Cancer Research
Background:
- Canine prostatic carcinoma (PC) treatment options are limited.
- Sparse literature exists on medical management of PC.
Purpose of the Study:
- To assess outcomes (MST, TTP) for canine PC treated with NSAIDs and/or chemotherapy.
- To identify prognostic factors in canine PC.
Main Methods:
- Retrospective study of 67 dogs with confirmed PC from 8 institutions.
- Analysis of treatment protocols (NSAIDs, chemotherapy, or combination) and prognostic factors.
- Evaluation of presenting signs, urine culture, and presence of metastases.
Main Results:
- Overall MST was 82 days, median TTP was 63 days.
- Combination NSAIDs and chemotherapy yielded significantly longer MST (106 vs 51 days) and TTP (76 vs 44 days) versus NSAIDs alone.
- Intact dogs and those with metastatic disease had significantly shorter MST and TTP.
Conclusions:
- Combination therapy of NSAIDs and chemotherapy may improve outcomes for canine PC.
- Metastatic disease and intact status are negative prognostic indicators for canine PC.
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