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Updated: Feb 10, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
Acylphloroglucinols as kinase inhibitors from Sargassum nigrifoloides
Cheng-Shi Jiang1, Yin-Yin Wang1, Jin-Tong Song1
1a School of Biological Science and Technology , University of Jinan , Jinan 250022 , China.
Abstract:
Three new acylphloroglucinols (1-3) and four known biosynthetically related analogs (4-7) were isolated from the ethanol extract of a brown alga Sargassum nigrifoloides. Structures for 1-7 were characterized via detailed spectroscopic analyses especially 2D NMR data. Screening of these compounds in Alzheimer's diseases-related bioassays revealed moderate inhibitory activities against two therapeutically important kinases, CDK5 and GSK3β. A preliminary structure-activity relationship was also discussed.
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