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Updated: Feb 10, 2026

Author Spotlight: Generation of and Comparison Between Patient-Derived Gastric Organoids from Different Regions of the Stomach
Published on: January 26, 2024
Alterations in mtDNA, gastric carcinogenesis and early diagnosis
S Rodrigues-Antunes1, B N Borges1
1a Laboratório de Biologia Molecular "Francisco Mauro Salzano" , Instituto de Ciências Biológicas, Universidade Federal do Pará , Belém , Brazil.
Abstract:
Gastric cancer remains one of the most prevalent cancers in the world. Due to this, efforts are being made to improve the diagnosis of this neoplasm and the search for molecular markers that may be involved in its genesis. Within this perspective, the mitochondrial DNA is considered as a potential candidate, since it has several well documented changes and is readily accessible. However, numerous alterations have been reported in mtDNA, not facilitating the visualization of which alterations and molecular markers are truly involved with gastric carcinogenesis. This review presents a compilation of the main known changes relating mtDNA to gastric cancer and their clinical significance.
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