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Pediatric reference intervals for general clinical chemistry components - merging of studies from Denmark and Sweden

Peter Ridefelt1, Linda Hilsted2, Anders Juul3

  • 1a Department of Medical Sciences, Clinical Chemistry , Uppsala University , Uppsala , Sweden.

Scandinavian Journal of Clinical and Laboratory Investigation
|May 29, 2018
PubMed

Insights

This study merges pediatric reference interval data from Denmark and Sweden, establishing age- and gender-specific clinical chemistry values for children aged 6 months to 18 years. These new reference intervals enhance diagnostic accuracy for pediatric healthcare.

Area of Science:

  • Clinical Chemistry
  • Pediatric Reference Intervals
  • Biostatistics

Background:

  • Reference intervals are vital for clinical decision-making but are often incomplete for pediatric populations.
  • Existing pediatric reference interval studies lack comprehensive data, particularly for younger children.
  • This study addresses the need for robust reference intervals in children and adolescents.

Purpose of the Study:

  • To combine data from separate pediatric reference interval studies in Denmark and Sweden.
  • To establish comprehensive, age- and gender-specific reference intervals for pediatric clinical chemistry components.
  • To include pre-school children, who were underrepresented in previous studies.

Main Methods:

  • Merged data from 1988 healthy children and adolescents (6 months to 18 years).
  • Measured 18 general clinical chemistry components using Abbott and Roche platforms.
  • Utilized NFKK Reference Serum X for commutability and calculated 2.5 and 97.5 percentiles.

Main Results:

  • Established age- and gender-specific pediatric reference intervals for 18 clinical chemistry analytes.
  • Increased sample size by merging data from two independent studies.
  • Provided a more complete dataset including pre-school aged children.

Conclusions:

  • The generated pediatric reference intervals are applicable to Nordic populations and can be validated for local use.
  • This study provides valuable data for improving diagnostic accuracy in pediatric healthcare.
  • Enhanced reference intervals support better clinical decisions for children and adolescents.
Abstract

Keywords:
Adolescentsbiomarkerschildrenclinical chemistry testsreference standardsreference values

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