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Near final height in patients with idiopathic growth hormone deficiency: A single-centre experience

Erdal Kurnaz1, Semra Çetinkaya1, Zehra Aycan1

  • 1Clinic of Pediatric Endocrinology, Dr. Sami Ulus Obstetrics and Gynecology and Pediatrics Training and Research Hospital, Ankara, Turkey.

Journal of Paediatrics and Child Health
|May 29, 2018
PubMed

Insights

Children with growth hormone deficiency (GHD) treated with recombinant human growth hormone (rhGH) can achieve near final height (NFH) within the mid-parental height range. Starting rhGH therapy during puberty may lead to greater height gains.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Genetics

Background:

  • Growth hormone deficiency (GHD) impacts children's final height.
  • Recombinant human growth hormone (rhGH) is a standard treatment for GHD.
  • Understanding factors influencing near final height (NFH) is crucial for optimizing treatment outcomes.

Purpose of the Study:

  • To analyze near final height (NFH) data in children with GHD treated with rhGH.
  • To compare NFH outcomes between isolated GHD (IGHD) and multiple pituitary hormone deficiency (MPHD) groups.
  • To evaluate the impact of pubertal status on rhGH treatment efficacy.

Main Methods:

  • Retrospective analysis of NFH data in children with GHD receiving rhGH therapy.
  • Patients were categorized into IGHD and MPHD groups.
  • Data were further stratified by gender, pre-pubertal/pubertal status, and puberty type.

Main Results:

  • rhGH therapy initiated at a median age of 12.1 years for IGHD and 9.1 years for MPHD.
  • Height Standard Deviation Scores (SDSs) at therapy onset were significantly lower in the MPHD group.
  • NFH SDSs were comparable between groups (-1.8 for IGHD, -1.6 for MPHD), but delta height SDSs were significantly higher in the MPHD group (2.6 vs 1.4).
  • Total height gain was similar for pre-pubertal (1.4 SDS) and pubertal (1.3 SDS) starters.

Conclusions:

  • Approximately 85% of patients achieved their genetic height potential.
  • Greater height gains (delta height SDSs) were observed in patients initiating rhGH treatment during puberty.
  • Achieving NFH within the mid-parental height range is feasible for patients starting rhGH therapy during puberty.
Abstract

Keywords:
final heightisolated growth hormone deficiencymultiple pituitary hormone deficiencypuberty

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