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Updated: Feb 10, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
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Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

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Association between seizure frequency and fatigue levels in children with epilepsy

Hideaki Kanemura1, Fumikazu Sano1, Tetsuo Ohyama1

  • 1Department of Paediatrics, Faculty of Medicine, Graduate School, University of Yamanashi, Yamanashi, Japan.

Journal of Paediatrics and Child Health
|May 29, 2018
PubMed

Insights

Children with epilepsy experience more fatigue, especially those with frequent seizures. Improving seizure control may reduce fatigue and enhance their quality of life.

Area of Science:

  • Pediatric Neurology
  • Epilepsy Research
  • Quality of Life Studies

Background:

  • Fatigue is a common and debilitating symptom in children with epilepsy.
  • Understanding the relationship between seizure control and fatigue is crucial for effective management.

Purpose of the Study:

  • To investigate the association between seizure-related features and fatigue levels in pediatric epilepsy patients.
  • To compare fatigue levels across different seizure control categories.

Main Methods:

  • Children with epilepsy were categorized into well-controlled (WCE), intermediate-controlled (ICE), and uncontrolled (UCE) groups based on seizure frequency.
  • Fatigue was assessed using the Fatigue Severity Scale (FSS) on a 7-point scale.
  • Multiple linear regression analysis was employed to identify factors associated with fatigue.

Main Results:

  • Children with epilepsy reported significantly higher FSS scores than healthy controls (4.40 vs. 1.55).
  • Seizure frequency was the sole significant predictor of fatigue (P < 0.0001).
  • Mean FSS scores increased with poorer seizure control: WCE (2.30), ICE (3.97), and UCE (6.28), with UCE showing significantly higher fatigue than WCE.

Conclusions:

  • Seizure frequency is directly associated with fatigue severity in children with epilepsy.
  • Effective seizure control is a potential strategy to alleviate fatigue and improve the overall quality of life for these children.
Abstract

Keywords:
Fatigue Severity Scaleepilepsyfatiguequality of lifeseizure frequency

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