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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

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Androgen blockade based clinical trials landscape in triple negative breast cancer

Yaqin Shi1, Fang Yang1, Doudou Huang1

  • 1Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|May 29, 2018
PubMed

Insights

Androgen receptor (AR) targeted therapy shows promise for triple-negative breast cancer (TNBC). Combining AR blockade with other treatments may overcome resistance and improve outcomes for TNBC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling

Background:

  • Triple-negative breast cancer (TNBC) remains a challenging subtype with limited targeted therapies.
  • Androgen receptor (AR) signaling is increasingly recognized as a potential therapeutic target in TNBC.
  • Understanding AR-associated pathways is crucial for developing effective treatment strategies.

Purpose of the Study:

  • To elucidate the biological interactions of AR signaling in TNBC.
  • To explore combination strategies involving AR-targeted therapy.
  • To identify new avenues for endocrine-based treatment in TNBC.

Main Methods:

  • Preclinical studies investigating AR signaling pathways.
  • Clinical studies evaluating combination therapies.
  • Analysis of AR's interaction with PI3K/AKT/mTOR, cell cycle, and DNA damage repair pathways.

Main Results:

  • AR signaling interacts with key pathways (PI3K/AKT/mTOR, cell cycle, DNA repair) in TNBC.
  • AR signaling influences tumor initiation and immune modulation.
  • Preclinical studies show benefits of androgen-blockade combination therapy.
  • Clinical trials combining AR-targeted therapy with CDK4/6 inhibitors, PI3K inhibitors, chemotherapy, and immunotherapy are ongoing.

Conclusions:

  • AR signaling plays a pivotal role in TNBC pathogenesis.
  • Combination therapies targeting AR and associated pathways offer a promising strategy.
  • Clinical interpretation of AR-related interactions may lead to novel endocrine-based treatments for TNBC.
Keywords:
AndrogenBreastCombinationReceptorTriple

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