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Diagnostic accuracy of plasma atrial natriuretic peptide concentrations in cats with and without cardiomyopathies

Y Heishima1, Y Hori2, K Nakamura3

  • 1School of Veterinary Medicine, Rakuno Gakuen University, 582 Midoricho, Bunkyodai, Ebetsu, Hokkaido 069-8501, Japan; Heisei Animal Hospital, 2-1-1 Futago-cho, Kasugai, Aichi 486-0955, Japan.

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
|May 30, 2018
PubMed

Insights

Plasma atrial natriuretic peptide (ANP) levels are higher in cats with advanced cardiomyopathy. Measuring ANP offers valuable insights into the severity of cardiac disease in cats.

Area of Science:

  • Veterinary Cardiology
  • Biomarker Discovery

Background:

  • Plasma atrial natriuretic peptide (ANP) levels are reportedly elevated in cats with cardiomyopathy.
  • Cardiomyopathy is a significant concern in feline health, necessitating accurate diagnostic tools.

Purpose of the Study:

  • To investigate the diagnostic accuracy of plasma ANP concentration as an indicator of cardiomyopathy severity in cats.
  • To evaluate the utility of plasma ANP levels in differentiating between healthy cats and those with varying stages of cardiomyopathy.

Main Methods:

  • A prospective multicenter study involving 78 control cats and 83 cats with diagnosed cardiomyopathy.
  • Echocardiography was used to diagnose cardiomyopathy and categorize cats into groups: no left atrial dilation (LAD), LAD, and heart failure.
  • Plasma C-terminal ANP concentrations were measured using chemiluminescence.

Main Results:

  • Plasma ANP concentrations were significantly higher in cardiomyopathic cats with LAD and heart failure compared to controls.
  • A plasma ANP concentration >77.5 pg/mL showed 66.3% sensitivity and 84.6% specificity for identifying cardiomyopathy.
  • A threshold of >110.9 pg/mL demonstrated 73.6% sensitivity and 93.5% specificity for detecting LAD, with AUCs of 0.80 and 0.86 respectively.

Conclusions:

  • Plasma ANP concentrations correlate with the severity of cardiomyopathy in cats.
  • While not a standalone diagnostic test, plasma ANP measurement provides valuable supplementary information for assessing cardiac disease severity in felines.
Abstract

Keywords:
Cardiac biomarkerFelineHeart diseaseHeart failureHypertrophic cardiomyopathy

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