Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Assessing Body Temperature - Rectal01:27

Assessing Body Temperature - Rectal

12.6K
Rectal temperature measurement is considered the most precise method for assessing core body temperature and typically registers higher than oral temperature. For adults, the rectal thermometer should be inserted 1 to 1.5 inches into the rectum to obtain the most accurate reading.
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
12.6K
Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Total Voids in Concrete01:12

Total Voids in Concrete

494
Total voids in concrete encompass gel water volume, capillary pores, and entrapped air. Gel water (retained within the cement hydration products) and physically entrapped or adsorbed water are significant for the hydration process. For complete hydration, it's estimated that the space needed for the products of a cubic centimeter of cement doubles. Capillary pores constitute the unoccupied space within the hydrated cement paste, with their size largely influenced by the water-to-cement...
494
Group Therapy01:26

Group Therapy

454
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
454

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individualizing multi-modality therapy for locally advanced rectal cancer: incorporating new data into practice.

ESMO gastrointestinal oncology·2026
Same author

Conceptualising SEL in the Cross-Cultural Spaces of Primary Schools in Aotearoa New Zealand.

New Zealand journal of educational studies·2024
Same author

Outcome of neoadjuvant treatment for pancreatic cancer in elderly patients: comparative, observational cohort study.

The British journal of surgery·2021
Same author

A Phase 2 Multi-institutional Study to Evaluate Gemcitabine and Fractionated Stereotactic Radiotherapy for Unresectable, Locally Advanced Pancreatic Adenocarcinoma.

Practical radiation oncology·2014
Same author

Acute effects of pelvic irradiation on the adult uterus revealed by dynamic contrast-enhanced MRI.

The British journal of radiology·2013
Same author

Outcomes of induction chemotherapy followed by chemoradiation using intensity-modulated radiation therapy for esophageal adenocarcinoma.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2013

Related Experiment Video

Updated: Feb 10, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

6.6K

Total neoadjuvant therapy for rectal cancer.

K A Goodman1

  • 1University of Colorado Cancer Center, Professor, Department of Radiation Oncology, University of Colorado School of Medicine, 1665 Aurora Court, Suite 1032 MS F706, Aurora, CO 80045, USA.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|May 30, 2018
PubMed
Summary

For locally advanced rectal cancer, total neoadjuvant therapy is gaining traction to combat distant progression. This approach optimizes chemotherapy delivery before surgery, aiming to improve patient outcomes and reduce treatment-related toxicity.

Keywords:
Cancer rectal localement évoluéChemoradiationChimioradiothérapieChimiothérapie d’inductionInduction chemotherapyLocally advanced rectal cancerThérapie néoadjuvante totaleTotal neoadjuvant therapy

More Related Videos

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
08:45

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Published on: November 13, 2012

14.3K
Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
04:05

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Published on: August 22, 2025

844

Related Experiment Videos

Last Updated: Feb 10, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

6.6K
Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
08:45

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Published on: November 13, 2012

14.3K
Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
04:05

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy

Published on: August 22, 2025

844

Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Combined modality therapy has improved outcomes for locally advanced rectal cancer.
  • Distant progression, not local failure, is now the primary cause of death.
  • There is a need for risk-adapted treatment strategies focusing on micrometastatic disease.

Purpose of the Study:

  • To review the emerging literature on treatment sequencing for locally advanced rectal cancer.
  • To critically appraise the total neoadjuvant therapy paradigm.
  • To explore options for omitting components of multimodality therapy.

Main Methods:

  • Literature review of emerging studies.
  • Focus on neoadjuvant chemotherapy sequencing.
  • Analysis of total neoadjuvant therapy and de-escalation strategies.

Main Results:

  • Increasing interest in neoadjuvant chemotherapy over postoperative chemotherapy.
  • Total neoadjuvant therapy is a key emerging paradigm.
  • Investigating the potential to omit certain treatment components.

Conclusions:

  • Risk-adapted strategies are crucial for locally advanced rectal cancer.
  • Neoadjuvant chemotherapy is increasingly favored to address micrometastatic disease.
  • Future research should focus on optimizing treatment sequencing and de-escalation.