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Evaluation index for asymmetric ventricular size on brain magnetic resonance images in very low birth weight infants

Toshihiko Ikuta1, Masami Mizobuchi2, Yoshinori Katayama3

  • 1Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan; Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.

Brain & Development
|May 30, 2018
PubMed

Insights

A new Lateral Ventricular Index (LVI) using MRI can predict walking disability in very low birth weight infants (VLBWI). Higher LVI values indicate a greater risk of walking impairment at 18 months corrected age.

Area of Science:

  • Neonatal Neurology
  • Pediatric Radiology
  • Developmental Pediatrics

Background:

  • Asymmetric ventriculomegaly on MRI in very low birth weight infants (VLBWI) is often linked to white matter injury.
  • Currently, no established index quantifies asymmetric ventricular size (left-right, anterior-posterior) in VLBWI.

Purpose of the Study:

  • To establish a novel evaluation index, the Lateral Ventricular Index (LVI), for assessing asymmetric ventricular size in VLBWI.
  • To investigate the relationship between the LVI and the likelihood of walking ability at 18 months corrected age in VLBWI.

Main Methods:

  • A retrospective multicenter cohort study involving 294 VLBWI who underwent brain T2-weighted MRI at term-equivalent age.
  • Development of the LVI, calculated as the sum of widths of the four lateral ventricle horns, corrected for cerebral diameter, at the foramen of Monro level.
  • Analysis of the association between LVI values and walking status at 18 months corrected age.

Main Results:

  • Asymmetric ventricular sizes (left-right and anterior-posterior) were confirmed in VLBWI.
  • The LVI was significantly higher in infants who did not walk by 18 months (18.2) compared to those who did (15.8).
  • An LVI cut-off of 21.5 was identified, and values greater than 21.5 independently predicted walking disability (OR 2.56, p=0.008).

Conclusions:

  • The developed Lateral Ventricular Index (LVI) shows potential as a predictive tool for walking disability in VLBWI.
  • MRI-derived LVI measurements may aid in identifying VLBWI at risk for motor impairments, enabling timely interventions.
Abstract

Keywords:
Lateral ventricleMagnetic resonance imagingMotor developmentVery low birth weight infantsWalking

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