Related Experiment Video

Updated: Feb 10, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

13.5K

Does the use of an iodine-containing contrast agent to visualise the PICC tip in preterm babies cause hypothyroidism?

Chandra Prakash Rath1, Mary Thomas2, Drew Sullivan3

  • 1Department of Neonatology, King Edward Memorial Hospital, Perth, Western Australia, Australia.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|May 30, 2018
PubMed

Insights

Iodine-based contrast in preterm neonates did not affect thyroid function tests. However, it improved the certainty of peripherally inserted central catheter (PICC) tip positioning.

Area of Science:

  • Neonatal Medicine
  • Radiology
  • Endocrinology

Background:

  • Preterm neonates (<30 weeks) often require peripherally inserted central catheters (PICCs).
  • Assessing the safety and efficacy of procedures in this vulnerable population is crucial.
  • Iodine-based contrast agents are used in neonates, but their impact on thyroid function requires evaluation.

Purpose of the Study:

  • To compare thyroid function tests in preterm neonates exposed to iodine-based contrast with controls.
  • To ascertain the certainty of peripherally inserted central catheter (PICC) tip position after contrast administration.

Main Methods:

  • A randomized trial involving preterm neonates (<30 weeks) requiring a PICC.
  • Infants received either iodine-containing contrast or normal saline.
  • Thyroid-stimulating hormone (TSH) levels were measured on day 14 post-PICC insertion and day 28 of life.

Main Results:

  • No significant differences in TSH levels were observed between the contrast and control groups at day 14 or day 28.
  • PICC tip localization was more certain in the contrast-exposed group (85% vs. 55%).
  • Urinary iodine levels were significantly elevated in neonates who received contrast.

Conclusions:

  • Iodine-based contrast administration in preterm neonates does not suppress subsequent thyroid function.
  • The use of contrast enhances the certainty of peripherally inserted central catheter (PICC) tip visualization.
  • This suggests a potential benefit of contrast in improving procedural accuracy without compromising thyroid health.
Abstract

Keywords:
iodinepercutaneous catheterpretermthyroid function

More Related Videos

Preterm EEG: A Multimodal Neurophysiological Protocol19:32

Preterm EEG: A Multimodal Neurophysiological Protocol

Published on: February 18, 2012

29.0K
Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging11:27

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

10.6K

Related Concept Videos

Chemical Agents for Microbial Control01:27

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
921
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
429
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.8K
Phase Contrast and Differential Interference Contrast Microscopy01:26

Phase Contrast and Differential Interference Contrast Microscopy

Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
14.1K
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene01:13

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
7.5K