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Multidrug resistance in Gram-negative pathogens isolated from patients with chronic kidney diseases and renal

Bushra Jamil1, Mohammad Tauseef Mukhtar Bokhari2, Azhar Saeed2

  • 1National University of Medical Sciences, Rawalpindi.

JPMA. the Journal of the Pakistan Medical Association
|May 30, 2018
PubMed

Insights

Multidrug resistance in gram-negative pathogens is a growing clinical concern. This study found high rates of antibiotic resistance, particularly in chronic renal patients, highlighting an urgent need for effective treatment strategies.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Multidrug resistance (MDR) in gram-negative pathogens poses a significant threat to clinical practice.
  • The increasing prevalence of MDR necessitates understanding resistance patterns in local isolates.

Purpose of the Study:

  • To determine the prevalence and patterns of multidrug resistance in gram-negative clinical isolates.
  • To investigate the antibiotic resistance trends in specific gram-negative bacteria.

Main Methods:

  • Collection and processing of 8,300 clinical samples from June to October 2014.
  • Isolation and identification of 729 clinically significant gram-negative pathogens.
  • Phenotypic, biochemical, and antimicrobial resistance pattern analysis.

Main Results:

  • High prevalence of extended-spectrum beta-lactamase (ESBL) production: 100% in Klebsiella pneumoniae and 75% in Escherichia coli.
  • Significant carbapenem resistance observed: 79% in K. pneumoniae and 5.4% in E. coli.
  • Escalating resistance trends against fluoroquinolones and a drastic increase in antibiotic resistance among chronic renal patients.

Conclusions:

  • Gram-negative pathogens exhibit simultaneous resistance to multiple antibiotics.
  • The study highlights a concerning rise in antibiotic resistance, especially in vulnerable patient groups like those with chronic renal conditions.
  • Urgent interventions are required to combat the escalating threat of multidrug-resistant gram-negative infections.
Keywords:
Extended spectrum b-lactamase, Antibiotics, Multidrug-resistant pathogens, Klebsiella pneumonia, Escherichia coli.

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