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Related Concept Videos

Schemas01:42

Schemas

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A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
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The Participant-Reported Implementation Update and Score PRIUS: A Novel Method for Capturing Implementation-Related Data Over Time
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[Update: polyarteritis nodosa].

Jan H Schirmer1, Frank Moosig2

  • 1Klinik für Innere Medizin I, Sektion Rheumatologie, Exzellenzzentrum Entzündungsmedizin, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105, Kiel, Deutschland. JanHenrik.Schirmer@uksh.de.

Zeitschrift Fur Rheumatologie
|May 30, 2018
PubMed
Summary
This summary is machine-generated.

Polyarteritis nodosa (PAN) is a serious condition affecting medium-sized blood vessels. Treatment varies by PAN subtype, with some requiring immunosuppressants and others specific antiviral therapies.

Keywords:
Hepatitis BImmunosuppressivesNecrotizing arteritisPlasmapheresisVasculitis

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Area of Science:

  • Vascular Inflammation
  • Rheumatology
  • Immunology

Background:

  • Polyarteritis nodosa (PAN) is a life-threatening necrotizing arteritis affecting medium-sized vessels.
  • PAN commonly manifests in the skin, peripheral nervous system, and visceral organs, presenting diagnostic challenges.
  • Accurate diagnosis is crucial to differentiate PAN from other conditions like infections, malignancies, and drug-induced or other inflammatory diseases.

Purpose of the Study:

  • To provide a comprehensive overview of Polyarteritis nodosa (PAN).
  • To discuss the diagnostic work-up and classification of PAN variants.
  • To outline the distinct treatment strategies for different subtypes of PAN.

Main Methods:

  • Literature review of Polyarteritis nodosa (PAN).
  • Classification of PAN into idiopathic, hepatitis B-associated, hereditary inflammatory, and isolated cutaneous variants.
  • Discussion of diagnostic criteria and differential diagnoses for PAN.
  • Review of treatment modalities including immunosuppressants, virustatic agents, and plasmapheresis.

Main Results:

  • PAN affects medium-sized vessels and can be fatal if untreated.
  • Key manifestations include skin lesions, mononeuritis multiplex, and visceral vessel abnormalities.
  • Subclassification is essential as treatment differs significantly among variants.
  • Hepatitis B-associated PAN requires virustatic agents and plasmapheresis; other variants need immunosuppression.

Conclusions:

  • Polyarteritis nodosa (PAN) is a complex vasculitis with diverse clinical presentations.
  • Tailored treatment strategies based on PAN subclassification are critical for patient outcomes.
  • The isolated cutaneous variant of PAN generally has a favorable prognosis with less aggressive treatment.