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Related Concept Videos

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Persuasion is the process of changing our attitude toward something based on some kind of communication. Much of the persuasion we experience comes from outside forces. How do people convince others to change their attitudes, beliefs, and behaviors? What communications do you receive that attempt to persuade you to change your attitudes, beliefs, and behaviors?
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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
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Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
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Routes to, from and within the subiculum.

Claudia Böhm1,2, Yangfan Peng3,4, Jörg R P Geiger3

  • 1Neuroscience Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany. boehmc@janelia.hhmi.org.

Cell and Tissue Research
|May 30, 2018
PubMed
Summary

The subiculum acts as a crucial gateway for hippocampal information, processing and distributing memory data to various brain regions. Its unique cell properties enable parallel output streams for context-specific retrieval and behavior.

Keywords:
ConnectivityHippocampusOscillationPyramidal cellSubiculum

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Area of Science:

  • Neuroscience
  • Cellular Biology
  • Systems Neuroscience

Background:

  • The subiculum is a key hippocampal output region with extensive projections to extrahippocampal areas.
  • It plays a pivotal role in memory formation, consolidation, and retrieval.
  • The hippocampus requires a flexible network for encoding, distribution, storage, and integration of information.

Purpose of the Study:

  • To review the subiculum's role as a gateway between the hippocampus and cortex.
  • To summarize its integration into upstream and downstream circuits.
  • To discuss local network topology, cellular properties, and functional roles of subicular cell subtypes.

Main Methods:

  • Literature review and synthesis of existing research on the subiculum.
  • Analysis of the subiculum's connectivity and network topology.
  • Discussion of cellular and functional properties of subicular cell subtypes.

Main Results:

  • The subiculum integrates and processes hippocampal information before conveying it to cortical storage.
  • Its local network topology and cellular properties are crucial for information processing.
  • Subicular cell subtypes contribute to separating information into parallel output streams.

Conclusions:

  • The subiculum is essential for distributing hippocampal information to multiple target areas.
  • Its cellular and network properties facilitate context-specific memory retrieval and behavioral responses.
  • Understanding the subiculum's function is key to comprehending hippocampal-cortical interactions in memory.