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Updated: Feb 10, 2026
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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
Published on: March 17, 2015
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Cold sensitivity and associated factors: a nested case-control study performed in Northern Sweden
Albin Stjernbrandt1,2, Daniel Carlsson3, Hans Pettersson3
1Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, 901 87, Umeå, Sweden. albin.stjernbrandt@umu.se.
Summary
Cold sensitivity is linked to various health conditions and past injuries, including frostbite and migraines. However, being overweight appears to reduce the likelihood of reporting cold sensitivity.
Area of Science:
- Environmental Health
- Epidemiology
- Human Physiology
Background:
- Cold sensitivity is a common condition affecting individuals exposed to cold environments.
- Understanding the factors associated with cold sensitivity is crucial for prevention and management.
Purpose of the Study:
- To identify individual and external factors associated with reporting cold sensitivity.
- To compare cases of cold sensitivity with matched controls regarding anthropometry, medical history, and environmental exposures.
Main Methods:
- A population-based study was conducted in Northern Sweden with 12,627 participants aged 18-70.
- Cold sensitivity cases and matched controls were identified via questionnaire.
- Conditional logistic regression analysis was used to determine significant associations.
Main Results:
- Frostbite, rheumatic disease, upper extremity nerve injury, migraines, and vascular disease were significantly associated with cold sensitivity.
- A body mass index (BMI) of 25 or higher was inversely associated with reporting cold sensitivity.
- The study achieved an 81.7% response rate for the second questionnaire.
Conclusions:
- Cold sensitivity is associated with both individual factors and external exposures.
- Acquired conditions like frostbite, rheumatic diseases, nerve injuries, migraines, and vascular diseases increase the risk of cold sensitivity.
- Overweight individuals reported lower instances of cold sensitivity.
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