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Apparent Hyperthyroidism Caused by Biotin-Like Interference from IgM Anti-Streptavidin Antibodies
Leo Lam1, Warwick Bagg2,3, Geoff Smith4
11 Department of Chemical Pathology, LabPlus, Auckland City Hospital, Auckland City Hospital , Auckland, New Zealand .
Analytical interference from immunoglobulin M (IgM) anti-streptavidin antibodies can cause erroneous thyroid function tests. This rare interference mimics biotin effects and impacts multiple biotin-dependent immunoassays, leading to falsely high or low results.
Area of Science:
- Clinical Chemistry
- Immunology
- Laboratory Medicine
Background:
- Analytical interference in immunoassays can be mistaken for laboratory artifacts, complicating clinical interpretation.
- Discrepancies between clinical and laboratory findings necessitate the exclusion of analytical interference.
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