Apparent Hyperthyroidism Caused by Biotin-Like Interference from IgM Anti-Streptavidin Antibodies

Leo Lam1, Warwick Bagg2,3, Geoff Smith4

  • 11 Department of Chemical Pathology, LabPlus, Auckland City Hospital, Auckland City Hospital , Auckland, New Zealand .

Summary

Analytical interference from immunoglobulin M (IgM) anti-streptavidin antibodies can cause erroneous thyroid function tests. This rare interference mimics biotin effects and impacts multiple biotin-dependent immunoassays, leading to falsely high or low results.

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