Related Experiment Video
Updated: Feb 10, 2026

Development of an Innovative LED-based Illumination Device for In Vitro Application of Photodynamic Therapy with Rose Bengal
Published on: September 12, 2025
Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy
Xingshu Li1, Nahyun Kwon1, Tian Guo1
1Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120-750, Korea.
Abstract:
Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.
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