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Protective effects of tumor necrosis factor alpha inhibitors on methotrexate-induced pancreatic toxicity

Tolga Mercantepe1, Yıldıray Kalkan1, Levent Tumkaya1

  • 1Departments of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|May 30, 2018
PubMed
Abstract

Insights

Adalimumab (ADA) protects against methotrexate (MTX)-induced pancreatic damage. This study shows ADA reduces inflammation and cell death in the pancreas, offering a potential therapeutic strategy.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Oncology

Background:

  • Methotrexate (MTX) is widely used for cancer and inflammatory diseases.
  • MTX's pancreatic side effects and toxicity mechanisms are not well understood.
  • Pancreatic sensitivity to MTX toxicity is noted in high-dose studies.

Purpose of the Study:

  • To investigate the preventive effect of adalimumab (ADA) on MTX-induced pancreatic toxicity.
  • To evaluate ADA's impact on pancreatic tissue damage caused by MTX.

Main Methods:

  • Rats were divided into control, MTX, and MTX + ADA groups.
  • MTX (20 mg/kg) was administered intraperitoneally to Groups 2 and 3.
  • ADA (5 mg/kg) was administered intraperitoneally to Group 3.

Main Results:

  • MTX induced significant pancreatic edema, necrosis, and inflammation.
  • ADA treatment significantly reduced MTX-induced edema, necrosis, and inflammation.
  • MTX decreased insulin and somatostatin in islets; ADA treatment reversed this and improved pancreatic structure.

Conclusions:

  • Adalimumab (ADA) demonstrated a protective effect against MTX-induced pancreatic injury.
  • ADA may mitigate MTX-related pancreatic toxicity through anti-inflammatory and tissue-remodeling mechanisms.
Keywords:
adalimumabmethotrexatepancreasrattoxicity

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