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Changes in circulating microRNA-126 levels are associated with immune imbalance in children with acute asthma

Man Tian1, Yong Ji2, Tingting Wang3

  • 11 Department of Respiratory, Children's Hospital of Nanjing Medical University, Nanjing, P.R. China.

International Journal of Immunopathology and Pharmacology
|May 30, 2018
PubMed

Insights

MicroRNA-126 (miR-126) is overexpressed in children with acute asthma, correlating with immune imbalance and disease severity. This suggests miR-126 may serve as a potential biomarker for asthma diagnosis and evaluation.

Area of Science:

  • Immunology
  • Pulmonology
  • Molecular Biology

Background:

  • Asthma involves complex immune dysregulation.
  • MicroRNA-126 (miR-126) is implicated in immune responses.
  • Clinical significance of circulating miR-126 in pediatric asthma requires elucidation.

Purpose of the Study:

  • To investigate the clinical significance of miR-126 in the peripheral blood of children with acute asthma.
  • To correlate miR-126 levels with immune cell profiles and disease severity.
  • To assess the diagnostic and predictive value of miR-126 in asthma.

Main Methods:

  • Compared 80 children with acute asthma to 80 healthy children.
  • Measured circulating miR-126, IL-4, IFN-γ levels, and Th17 and CD4+CD25+Treg cell percentages.
  • Analyzed correlations between miR-126, immune markers, lung function, and asthma severity.

Main Results:

  • Children with asthma showed higher miR-126, IL-4, and Th17 cells, and lower IFN-γ and Treg cells compared to controls.
  • miR-126 levels positively correlated with IL-4 and Th17 cells, and negatively with IFN-γ, Treg cells, and lung function.
  • miR-126 and Treg cell percentages were highly predictive for asthma diagnosis.

Conclusions:

  • Overexpressed miR-126 in acute asthma is linked to immune imbalance.
  • miR-126 levels correlate with asthma severity and immune cell dynamics.
  • Circulating miR-126 shows potential as a serological marker for asthma diagnosis and severity assessment.

Keywords:
acute attackasthmachildrencytokineimmune celllung functionmicroRNA-126

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