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Updated: Feb 10, 2026

Micromanipulation of Chromosomes in Insect Spermatocytes
Published on: October 22, 2018
[X-chromosome loss can be an age-related phenomenon in women]
Anne Marie Jelsig1, Karen Brøndum-Nielsen, Asuram Zeynep Tümer
1anne.marie.jelsig@regionh.dk.
Abstract:
During chromosome analysis the finding of few cells with X-chromosome aneuploidy in a phenotypically normal woman is not unusual - so-called low-grade mosaicism for X aneuploidy (LLX-A). Such results can be difficult to interpret. In this review, LLX-A and its clinical implications are discussed, and based on the current literature it can be concluded, that LLX-A is an age-related phenomenon not related to reproductive issues such as recurrent abortions. This should be taken into account in any laboratory performing chromosome analysis.
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