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Related Experiment Video

Updated: Feb 10, 2026

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

Migraine improvement correlates with posterior cingulate cortical thickness reduction.

Vanise C G Amaral¹, Gustavo Tukamoto², Tadeu Kubo²

¹Departamento de Neurologia e Neurocirurgia, Universidade Estadual do Amazonas, Manaus, AM, Brasil.

Arquivos De Neuro-Psiquiatria

|May 30, 2018

Summary

Migraine patients show cortical thickness changes in visual and pain processing areas compared to controls. Improvement in headache frequency and intensity correlated with changes in the left posterior cingulate cortex.

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Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Published on: June 2, 2014

Area of Science:

Neuroscience
Medical Imaging

Background:

Migraine is a complex neurological disorder.
Understanding the underlying brain changes is crucial for effective treatment.

Purpose of the Study:

To correlate migraine improvement after prophylactic therapy with changes in cortical thickness.
To investigate the relationship between headache index and cortical alterations.

Main Methods:

Magnetic resonance imaging (MRI) was used to obtain cortical thickness maps from 19 migraine patients before and after treatment.
FreeSurfer software was employed for MRI analysis.
Cortical changes were correlated with the headache index (HI).

Main Results:

Patients with migraine exhibited increased cortical thickness in the right cuneus, precuneus, somatosensory, and superior parietal cortices compared to controls.
No significant cortical changes were observed between the first and second scans in patients.
A negative correlation was found between headache index improvement and cortical thickness changes in the left posterior cingulate cortex.

Conclusions:

Migraine patients display distinct cortical thickness patterns in brain regions associated with vision and pain processing.
Cortical changes in the left posterior cingulate cortex are linked to headache frequency and intensity, suggesting its role in pain modulation and chronic pain development.