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Updated: Feb 10, 2026
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Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons
Published on: May 25, 2015
18.2K
Is phrenic nerve conduction affected in patients with difficult-to-treat asthma?
Analúcia Abreu Maranhão1, Marcia Maria Jardim Rodrigues1, Sonia Regina da Silva Carvalho1
1Faculdade de Medicina, Universidade Federal do Estado Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Arquivos De Neuro-Psiquiatria
|May 30, 2018
Summary
Difficult-to-treat asthma patients show reduced phrenic neuroconduction without diaphragm electromyography changes. This may indicate diaphragm muscle fiber abnormalities from overload activity in asthma.
Area of Science:
- Respiratory Medicine
- Neurology
- Physiology
Background:
- Difficult-to-treat asthma often involves complex pathophysiology.
- Diaphragm function is crucial for respiration and can be affected by chronic respiratory diseases.
Purpose of the Study:
- To investigate phrenic neuroconduction and diaphragm electromyography in difficult-to-treat asthma.
- To compare these parameters between asthmatic patients and healthy controls.
Main Methods:
- Phrenic neuroconduction and diaphragm electromyography were performed.
- Spirometry, maximal respiratory pressures, and chest X-rays were also obtained.
- Study included 20 difficult-to-treat asthma patients and 27 controls.
Main Results:
- A reduced phrenic compound motor action potential area was observed in asthma patients compared to controls.
- Diaphragm electromyography results were normal in all asthma patients.
- Maximal inspiratory and expiratory pressures and spirometry data were also analyzed.
Conclusions:
- Reduced phrenic compound motor action potential area in asthma, without electromyography abnormalities, suggests potential diaphragm muscle fiber issues.
- This could be a consequence of chronic overload activity in the diaphragm of difficult-to-treat asthmatics.
- Further research into diaphragm muscle integrity is warranted.
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