Related Experiment Video

Updated: Feb 10, 2026

Guidelines for Elective Pediatric Fiberoptic Intubation
11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.6K

Effect of Cycloplegia on Optical Biometry in Pediatric Eyes

Usha K Raina, Shantanu Kumar Gupta, Anika Gupta

    Journal of Pediatric Ophthalmology and Strabismus
    |May 30, 2018
    PubMed

    Insights

    Cycloplegia significantly alters optical biometry in pediatric eyes, affecting axial length, corneal thickness, and anterior chamber depth. Careful interpretation is crucial for accurate measurements in children undergoing eye exams.

    Area of Science:

    • Ophthalmology
    • Pediatric Eye Care
    • Biometry

    Background:

    • Accurate optical biometry is essential for pediatric eye care.
    • Cycloplegia is commonly used in pediatric eye examinations.
    • Understanding cycloplegia's impact on biometry is critical for reliable measurements.

    Purpose of the Study:

    • To investigate the influence of cycloplegia on optical biometry parameters in pediatric eyes.
    • To assess changes in axial length, corneal thickness, anterior chamber depth, and lens thickness post-cycloplegia.
    • To evaluate these effects using the Lenstar LS 900 biometer.

    Main Methods:

    • Observational and comparative study including 56 normal and 20 cataractous pediatric eyes (ages 5-15).
    • Optical biometry measurements taken before and after topical 2% homatropine cycloplegia.
    • Statistical analysis using the Wilcoxon test to compare pre- and post-cycloplegia parameters.

    Main Results:

    • In normal eyes, cycloplegia caused significant decreases in axial length, central corneal thickness, and lens thickness, with increased anterior chamber depth.
    • In cataractous eyes, cycloplegia led to increased anterior chamber depth and decreased lens thickness.
    • All observed changes were statistically significant (P < .05 or P < .001).

    Conclusions:

    • Cycloplegia induces significant biometric changes in pediatric eyes.
    • Biometry measurements in children require careful interpretation considering the effects of cycloplegia.
    • Cycloplegia's impact underscores the need for standardized protocols in pediatric optical biometry.
    Abstract

    More Related Videos

    Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes09:20

    Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

    Published on: February 8, 2018

    11.4K
    Three-dimensional Optical-resolution Photoacoustic Microscopy08:31

    Three-dimensional Optical-resolution Photoacoustic Microscopy

    Published on: May 3, 2011

    18.9K

    Related Concept Videos

    Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

    Pharmacokinetics in Pediatric Patients: Drug Excretion

    In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
    274
    Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

    Pharmacokinetics in Pediatric Patients: Drug Distribution

    Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
    326
    Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

    Pharmacokinetics in Pediatric Patients: Drug Metabolism

    In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
    242
    Muscles of the Eye01:20

    Muscles of the Eye

    The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
    Extraocular Muscles
    The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
    4.5K
    Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

    Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

    Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
    305
    Accessory Structures of the Eye01:17

    Accessory Structures of the Eye

    Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
    3.8K