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Updated: Feb 10, 2026

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
Published on: September 27, 2024
[Osteonecrosis of the jaws (ONJ) associated to antiresorptive treatment]
Cecilia Larsson Wexell1, Anders Kjellman2, Olof Akre3
1Vastra Gotalandsregion - Avd. för käkkirurgi SÄS, Borås, Sweden - Avd. för käkkirurgi Borås, Sweden.
Abstract:
Osteonecrosis of the jaws (ONJ) has been associated to antiresorptive treatment and is an increasing problem all over the world. ONJ is a severe adverse effect of antiresorptive treatment with bisphosphonate and denosumab used for treatment of osteoporosis, metastases from certain malignant conditions and as an adjuvant treatment in postmenopausal women with breast cancer, and of treatment with certain chemotherapeutic drugs. In this paper the epidemiology, symptoms, diagnostic features, clinical findings, and treatment are reviewed. Guidelines are presented for dental treatment, surgery and referral of patients on antiresorptive treatment.
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