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Oxytocin does not influence adrenocorticotropin secretion in man
The Journal of Clinical Endocrinology and Metabolism
|January 1, 1985
Summary
Oxytocin does not significantly affect adrenocorticotropic hormone (ACTH) or cortisol levels in healthy men. This study found no evidence that oxytocin regulates pituitary-adrenal activity.
Area of Science:
- Neuroendocrinology
- Hormone Regulation
Background:
- Conflicting evidence exists regarding oxytocin's role in ACTH secretion.
- Animal studies suggest oxytocin may stimulate ACTH, while human studies propose inhibition.
Purpose of the Study:
- To investigate the effect of oxytocin on plasma ACTH and cortisol levels in normal men.
- To determine if oxytocin influences the hypothalamic-pituitary-adrenal (HPA) axis.
Main Methods:
- Four doses of oxytocin were administered via intravenous bolus injection.
- Prolonged oxytocin infusion was given during the early morning hours.
- Oxytocin pretreatment effects on vasopressin-induced responses were assessed.
Main Results:
- Oxytocin administration did not alter morning ACTH or cortisol levels compared to placebo.
- Prolonged oxytocin infusion did not suppress basal ACTH/cortisol or affect their circadian rhythm.
- Oxytocin pretreatment did not change ACTH and cortisol responses to vasopressin.
Conclusions:
- Oxytocin is not a significant regulator of pituitary-adrenal activity in healthy men.
- The findings do not support a major role for oxytocin in modulating the HPA axis in this population.