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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Risk of nosocomial infection with human T-cell lymphotropic virus III (HTLV-III)

M S Hirsch, G P Wormser, R T Schooley

    The New England Journal of Medicine
    |January 3, 1985
    PubMed

    Infection with human T-cell lymphotropic virus III (HTLV-III) is closely linked to the acquired immunodeficiency syndrome (AIDS). We evaluated the risk of nosocomial infection with HTLV-III by testing for antibodies to HTLV-III among hospital employees, including victims of needle-stick exposure, endoscopists, pathologists, and laboratory workers. Assays for antibody against the virus were performed by enzyme-linked immunosorbent assay and electrophoretic (Western blot) techniques. Although all 22 of our patients with AIDS and 6 of 7 with AIDS-related complex were found to have antibodies to HTLV-III when both assays were employed, none of the 85 employees with nosocomial exposure to specimens from patients with AIDS were positive for HTLV-III antibody. These studies must be regarded as preliminary, but they suggest that when current hospital isolation procedures are employed, the risk of nosocomial transmission of HTLV-III is low.

    Keywords:
    Acquired Immunodeficiency SyndromeAmericasDelivery Of Health CareDeveloped CountriesDeveloping CountriesDiseasesHealthHealth PersonnelHiv InfectionsHospital PersonnelNorth AmericaNorthern AmericaUnited StatesViral Diseases

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