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[Cardiovascular risk factors in patients after coarctation of aorta repair]

Beata Róg1, Magdalena Okólska1, Kinga Sałapa2

  • 1Cardiological Outpatient Clinic, John Paul II Hospital, Krakow.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|May 30, 2018
PubMed

Insights

Adults treated for coarctation of the aorta have increased cardiovascular risk factors, including higher blood pressure, glucose, and inflammation markers compared to healthy individuals. These findings highlight the need for ongoing monitoring and management of atherosclerosis risk in this population.

Area of Science:

  • Cardiology
  • Vascular Surgery
  • Preventive Medicine

Background:

  • Coarctation of the aorta (CoA) is a congenital narrowing of the thoracic aorta.
  • Surgical repair is the standard treatment for CoA.
  • Long-term outcomes and associated risks in adult patients post-CoA repair require further investigation.

Purpose of the Study:

  • To assess atherosclerosis risk factors in adult patients who underwent surgical treatment for aortic coarctation.
  • To compare these risk factors with a control group of healthy volunteers.

Main Methods:

  • A cohort of 58 adult patients (median age 27.46) post-CoA surgery was compared with 30 age- and sex-matched healthy volunteers.
  • Analysis included arterial blood pressure, lipid profile, fasting glucose, inflammation markers (hsCRP, fibrinogen), and lifestyle factors.

Main Results:

  • CoA patients exhibited significantly higher systolic blood pressure, fasting glucose, hsCRP, and fibrinogen levels compared to controls.
  • Hyperlipidemia was more prevalent in CoA patients (44.8% vs 23.3%).
  • Hypertensive CoA patients were older and had higher body weight, with increased prevalence of hypoplastic aortic arch, recoarctation, cardiovascular disease, and family history.

Conclusions:

  • Coarctation of the aorta is associated with elevated cardiovascular risk in adulthood.
  • This increased risk is attributed to higher levels of arterial hypertension, hyperlipidemia, glucose, and inflammation markers.
  • Adults with a history of CoA require diligent monitoring for cardiovascular risk factors.

Keywords:
cardiovascular risk factorscoarctation of aortacongenital heart disease

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