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Myocardial dysfunction in septic shock.

R H Carmona, T Tsao, M Dae

    Archives of Surgery (Chicago, Ill. : 1960)
    |January 1, 1985
    PubMed
    Summary
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    Septic shock causes myocardial depression through toxic factors affecting heart cells. This study found abnormal cell structure and function, independent of other causes, indicating a need for further research into these toxins.

    Area of Science:

    • Cardiology
    • Cell Biology
    • Biochemistry

    Background:

    • Myocardial depression is a significant, poorly understood aspect of septic shock.
    • Existing research has not fully elucidated the cellular mechanisms behind septic myocardial dysfunction.

    Purpose of the Study:

    • To investigate the morphologic and biochemical abnormalities in myocardial cells during septic shock.
    • To identify potential toxic factors contributing to cardiac dysfunction in sepsis.

    Main Methods:

    • Incubation of myocardial cells in normal and septic plasma under controlled conditions.
    • Measurement of cyclic adenosine monophosphate (cAMP), lactic dehydrogenase (LDH), and creatine kinase levels.
    • Electron microscopy to assess cellular structure.

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    Main Results:

    • Elevated LDH and creatine kinase in septic plasma indicate cell damage.
    • Reduced cAMP levels in septic conditions suggest impaired cellular signaling.
    • Septic myocardial cells exhibited irregular beating, arrest, and abnormal ultrastructure.

    Conclusions:

    • Septic myocardial dysfunction is linked to endogenous toxic factors.
    • The observed cellular abnormalities occur independently of controlled variables.
    • Further research is warranted to identify and characterize these myocardial toxins.