Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Islet cell carcinomas in dogs.

G Bestetti, G L Rossi

    Virchows Archiv. A, Pathological Anatomy and Histopathology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Insulin is the most reliable marker for canine islet cell carcinomas, appearing in all studied tumors. Metastases showed fewer hormone-producing cells than primary tumors.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The influence of acute exercise on bone biomarkers: protocol for a systematic review with meta-analysis.

    Systematic reviews·2020
    Same author

    Chagas disease knocks on our door: a cross-sectional study among Latin American immigrants in Milan, Italy.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018
    Same author

    Lab-scale tests and numerical simulations for in situ treatment of polluted groundwater.

    Journal of hazardous materials·2015
    Same author

    Spatio-temporal variability of airborne bacterial communities and their correlation with particulate matter chemical composition across two urban areas.

    Applied microbiology and biotechnology·2015
    Same author

    Quantitative evaluation of hidden defects in cast iron components using ultrasound activated lock-in vibrothermography.

    The Review of scientific instruments·2012
    Same author

    Antibiotic resistance in bacteria associated with coarse atmospheric particulate matter in an urban area.

    Journal of applied microbiology·2011

    Area of Science:

    • Veterinary Pathology
    • Endocrinology
    • Oncology

    Background:

    • Islet cell carcinomas are neoplasms of the pancreas.
    • These tumors can secrete various hormones, affecting canine health.
    • Understanding tumor markers is crucial for diagnosis and prognosis.

    Purpose of the Study:

    • To investigate the immunohistochemical expression of hormones in canine islet cell carcinomas.
    • To identify reliable markers for these tumors.
    • To compare hormone expression in primary tumors versus metastases.

    Main Methods:

    • Conventional and immunohistochemical light and electron microscopy were used.
    • Antisera against insulin, pancreatic polypeptide, somatostatin, and glucagon were employed.
    • Seven cases of canine islet cell carcinomas were analyzed.

    Related Experiment Videos

    Main Results:

    • Insulin was detected in all seven tumors, making it a potential marker.
    • Six tumors expressed multiple hormones; glucagon was never detected.
    • Liver metastases exhibited reduced immunoreactive cells compared to primary tumors.
    • Some cell types present in primary tumors were absent in metastases.

    Conclusions:

    • Insulin appears to be a consistent marker for canine islet cell carcinomas.
    • Hormonal expression differs between primary tumors and their metastases.
    • Further research is warranted to understand the implications of these findings.