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Effect of naloxone on oxytocin-induced cortisol decrease in normal men.

V Coiro, P Chiodera, G Rossi

    Acta Endocrinologica
    |February 1, 1985
    PubMed
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    Oxytocin reduces adrenocorticotropic hormone (ACTH)-cortisol levels in men. Naloxone, an opioid antagonist, blocks this effect, indicating that an opioid pathway mediates oxytocin

    Area of Science:

    • Endocrinology
    • Neuroscience

    Background:

    • Oxytocin administration intravenously (IV) reduces plasma adrenocorticotropic hormone (ACTH) and cortisol levels in healthy males.
    • Naloxone, a specific opioid antagonist, stimulates cortisol release, suggesting opioid peptides inhibit ACTH-cortisol secretion.

    Purpose of the Study:

    • To investigate whether an opioid pathway mediates the action of oxytocin.
    • To evaluate the effect of naloxone on oxytocin-induced cortisol decrease.

    Main Methods:

    • Six healthy males received IV oxytocin (2 IU bolus), naloxone (4 mg bolus + 10 mg infusion for 2 hours), or a combination.
    • Plasma cortisol levels were measured before and 2 hours after treatment.

    Main Results:

    • Oxytocin significantly decreased cortisol secretion.

    Related Experiment Videos

  • Naloxone administration stimulated plasma cortisol levels.
  • Naloxone abolished the cortisol-lowering effect of oxytocin when co-administered.

    • Conclusions:

    • Oxytocin's inhibitory action on ACTH-cortisol secretion in humans requires an active opioid system.
    • The findings suggest that oxytocin's effect on cortisol may be mediated through an opioid pathway.